DOC2A

Across TCGA cell cohorts, DOC2A RNA expression is significantly associated with the go_rna of many other GO terms, with 5,111 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DOC2A-associated GO terms across cancer lineages are Negative regulation of gene expression, epigenetic, Cytoplasmic translation, and Epigenetic regulation of gene expression. Each is linked with DOC2A in more than 12 cancer types. Because this analysis shows association rather than direction, both DOC2A-to-partner and partner-to-DOC2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of gene expression, epigenetic grouped by DOC2A-low versus DOC2A-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DOC2A→partner) and Y-score (partner→DOC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Negative regulation of gene expression, epigenetic →	+0.072	+1.477	.001	.002	3	13
OESOPHAGUS	Cytoplasmic translation →	+0.149	+2.171	<.001	<.001	3	13
BONE	Epigenetic regulation of gene expression →	+0.078	+2.024	.003	<.001	3	12
OESOPHAGUS	Regulation of syncytium formation by plasma membrane fusion →	+0.145	+1.924	<.001	<.001	3	12
OESOPHAGUS	Regulation of myoblast fusion →	+0.174	+2.128	<.001	<.001	3	12
BONE	Regulation of DNA repair →	+0.062	+1.926	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,111 associations by consensus.

Negative regulation of gene expression, epigenetic by DOC2A expression — STOMACH

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