DOC2A

Across TCGA cell cohorts, DOC2A mutation is significantly associated with the RNA expression of many other genes, with 38 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DOC2A-associated genes across cancer lineages are SLC32A1, GML, and IL2. Each is linked with DOC2A in more than 1 cancer types. Because this analysis shows association rather than direction, both DOC2A-to-partner and partner-to-DOC2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC32A1 grouped by DOC2A-low versus DOC2A-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DOC2A→partner) and Y-score (partner→DOC2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SLC32A1 →	+1.108	+3.901	<.001	.006	3	1
BLOOD_Leukemia	GML →	+0.110	+4.567	<.001	.001	3	1
BLOOD_Leukemia	IL2 →	+0.794	+4.691	<.001	<.001	3	1
BLOOD_Leukemia	IL17F →	+0.070	+3.855	<.001	.007	3	1
BLOOD_Leukemia	GZMK →	+0.448	+4.037	.004	.004	3	1
BLOOD_Leukemia	NPFFR1 →	+0.015	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

SLC32A1 by DOC2A expression — BLOOD_Leukemia

Explore this box plot interactively →