DNTTIP1

Across TCGA patient cohorts, DNTTIP1 mutation is significantly associated with the RNA expression of many other genes, with 650 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNTTIP1-associated genes across cancer lineages are RPS29P4, RN7SL447P, and SLC25A31. Each is linked with DNTTIP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNTTIP1-to-partner and partner-to-DNTTIP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS29P4 grouped by DNTTIP1-low versus DNTTIP1-high in THCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTTIP1→partner) and Y-score (partner→DNTTIP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
THCA	RPS29P4 →	+0.184	+7.962	<.001	.007	3	2
SKCM	RN7SL447P →	+0.098	+4.385	<.001	.008	3	2
UCEC	SLC25A31 →	+0.111	+3.368	.003	<.001	3	2
UCEC	RNU6-508P →	+0.373	+3.579	<.001	.002	3	2
UCEC	PSAT1P4 →	+0.183	+2.422	<.001	.001	3	2
THCA	MTND2P39 →	+0.044	+7.962	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 650 associations by consensus.

RPS29P4 by DNTTIP1 expression — THCA

Explore this box plot interactively →