DNTT

Across TCGA patient cohorts, DNTT protein abundance is significantly associated with the RNA expression of many other genes, with 143 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DNTT-associated genes across cancer lineages are AP4S1, PNN, and LEPROTL1. Each is linked with DNTT in more than 1 cancer types. Because this analysis shows association rather than direction, both DNTT-to-partner and partner-to-DNTT results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNTT versus AP4S1 in CCRCC, with a Pearson correlation of 0.58.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTT→partner) and Y-score (partner→DNTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	AP4S1 →	+0.379	+0.625	.001	.003	3	1
CCRCC	PNN →	+0.433	+0.826	.003	.001	3	1
CCRCC	LEPROTL1 →	+0.708	+0.719	<.001	.009	3	1
CCRCC	LENG1 →	+0.680	+0.672	.005	.003	3	1
CCRCC	PDE10A →	-2.865	-0.844	<.001	.007	3	1
CCRCC	LRRC31 →	-1.390	-0.826	.004	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 143 associations by consensus.

DNTT vs AP4S1 — CCRCC

Explore this scatter interactively →