DNTT

Across TCGA patient cohorts, DNTT mutation is significantly associated with the RNA expression of many other genes, with 4,778 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNTT-associated genes across cancer lineages are PHF7, TMEM62, and DCLRE1A. Each is linked with DNTT in more than 2 cancer types. Because this analysis shows association rather than direction, both DNTT-to-partner and partner-to-DNTT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF7 grouped by DNTT-low versus DNTT-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTT→partner) and Y-score (partner→DNTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PHF7 →	+0.713	+3.183	<.001	.009	3	3
UCEC	TMEM62 →	+0.431	+1.584	.004	.005	3	3
UCEC	DCLRE1A →	+0.456	+1.857	<.001	<.001	3	3
UCEC	SLC26A6 →	+0.526	+3.906	<.001	<.001	3	3
UCEC	CENPU →	+0.589	+2.321	.001	.006	3	3
UCEC	ZFYVE19 →	+0.455	+1.847	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,778 associations by consensus.

PHF7 by DNTT expression — COAD

Explore this box plot interactively →