DNTT

Across TCGA patient cohorts, DNTT mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNTT-associated genes across cancer lineages are TFRC, EGFR, and FoxM1. Each is linked with DNTT in more than 2 cancer types. Because this analysis shows association rather than direction, both DNTT-to-partner and partner-to-DNTT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TFRC grouped by DNTT-low versus DNTT-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTT→partner) and Y-score (partner→DNTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TFRC →	+0.617	+3.195	.018	.010	3	3
UCEC	EGFR →	-0.170	-1.807	.003	.025	3	2
UCEC	FoxM1 →	+0.228	+1.584	.014	.019	3	2
UCEC	GAPDH →	+0.422	+2.459	.029	.018	3	2
UCEC	JNK_pT183_Y185 →	-0.172	-2.415	.004	.003	3	2
UCEC	mTOR_pS2448 →	-0.146	-1.584	.006	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

TFRC by DNTT expression — COAD

Explore this box plot interactively →