DNTT

Across TCGA cell cohorts, DNTT mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNTT-associated genes across cancer lineages are IFNA6, VCY1B, and VCY. Each is linked with DNTT in more than 1 cancer types. Because this analysis shows association rather than direction, both DNTT-to-partner and partner-to-DNTT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA6 grouped by DNTT-low versus DNTT-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNTT→partner) and Y-score (partner→DNTT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IFNA6 →	+0.026	+4.887	<.001	.009	3	1
OVARY	VCY1B →	+0.283	+4.029	<.001	.009	3	1
OVARY	VCY →	+0.286	+4.228	<.001	.006	3	1
OVARY	GP9 →	+0.032	+4.029	<.001	.009	3	1
SKIN	H2AC21 →	+0.335	+3.719	.001	.001	3	1
LARGE_INTESTINE	SSMEM1 →	+0.027	+3.707	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IFNA6 by DNTT expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →