DNPEP

Across TCGA pan-cancer cohorts, DNPEP mass-spec protein is linked to patient survival in 9 of 34 cancer types, making it a survival-associated DNPEP data layer compared with 26 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DNPEP mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNPEP expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

COAD, HNSC, and PDAC are the cancer types where DNPEP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.906	1.000	.007	72	view →
HNSC	DFS	Tertile	All	0.985	0.416	.008	28	view →
PDAC	DFS	Tertile	All	0.613	0.328	.010	27	view →
UCEC	OS	Quartile	II,III,IV	0.358	1.000	.011	24	view →
LUAD	DFS	Median	All	0.949	0.356	<.001	21	view →
LSCC	OS	Tertile	II,III,IV	0.533	0.883	.009	9	view →
CCRCC	DFS	Quartile	II,III,IV	0.904	0.125	.024	9	view →
OV	DFS	Median	All	0.665	0.880	.045	4	view →
GBM	DFS	Median	All	0.238	0.506	.003	4	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

DNPEP–COAD (DFS)

Open the COAD breakdown →