DNPEP

Across TCGA patient cohorts, DNPEP protein abundance is significantly associated with the RNA expression of many other genes, with 14,042 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DNPEP-associated genes across cancer lineages are KPNA2, KIF23, and CEP55. Each is linked with DNPEP in more than 7 cancer types. Because this analysis shows association rather than direction, both DNPEP-to-partner and partner-to-DNPEP results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNPEP versus KPNA2 in LUAD, with a Pearson correlation of -0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNPEP→partner) and Y-score (partner→DNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	KPNA2 →	-1.045	-0.287	<.001	<.001	3	8
LUAD	KIF23 →	-1.133	-0.308	<.001	<.001	3	7
LUAD	CEP55 →	-1.247	-0.315	<.001	<.001	3	7
LUAD	NCAPG →	-1.233	-0.311	<.001	<.001	3	7
LUAD	SKA1 →	-1.154	-0.345	<.001	<.001	3	7
LSCC	COL4A3 →	+1.104	+0.271	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,042 associations by consensus.

DNPEP vs KPNA2 — LUAD

Explore this scatter interactively →