DNPEP

Across TCGA patient cohorts, DNPEP mutation is significantly associated with the RNA expression of many other genes, with 1,329 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNPEP-associated genes across cancer lineages are OR5W1P, RNA5SP412, and BTBD6. Each is linked with DNPEP in more than 2 cancer types. Because this analysis shows association rather than direction, both DNPEP-to-partner and partner-to-DNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR5W1P grouped by DNPEP-low versus DNPEP-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNPEP→partner) and Y-score (partner→DNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR5W1P →	+0.022	+4.049	<.001	.007	3	3
UCEC	RNA5SP412 →	+0.845	+2.967	<.001	<.001	3	2
SKCM	BTBD6 →	+0.622	+3.328	.003	.005	3	2
LUAD	LINC02503 →	+0.066	+5.279	.007	.006	3	2
COAD	TRGJP2 →	+0.981	+4.489	<.001	.002	3	2
SKCM	RTN3 →	+0.537	+3.341	.007	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,329 associations by consensus.

OR5W1P by DNPEP expression — SKCM

Explore this box plot interactively →