DNPEP

Across TCGA patient cohorts, DNPEP mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNPEP-associated genes across cancer lineages are mTOR_pS2448, Annexin_VII, and Shc_pY317. Each is linked with DNPEP in more than 1 cancer types. Because this analysis shows association rather than direction, both DNPEP-to-partner and partner-to-DNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DNPEP-low versus DNPEP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNPEP→partner) and Y-score (partner→DNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.152	-2.321	.042	.035	3	2
UCEC	Annexin_VII →	-0.166	-2.321	.017	.035	3	2
UCEC	Shc_pY317 →	-0.192	-3.459	.011	.005	3	2
UCEC	EGFR_pY1068 →	-0.278	-3.169	.027	.019	3	1
UCEC	EGFR →	-0.208	-2.321	.009	.035	3	1
UCEC	STAT3_pY705 →	-0.441	-3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

mTOR_pS2448 by DNPEP expression — UCEC

Explore this box plot interactively →