DNPEP

Across TCGA cell cohorts, DNPEP mutation is significantly associated with the RNA expression of many other genes, with 74 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNPEP-associated genes across cancer lineages are B9D1, TTK, and CCNG1. Each is linked with DNPEP in more than 1 cancer types. Because this analysis shows association rather than direction, both DNPEP-to-partner and partner-to-DNPEP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, B9D1 grouped by DNPEP-low versus DNPEP-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNPEP→partner) and Y-score (partner→DNPEP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	B9D1 →	+0.717	+3.299	.003	.004	3	1
LARGE_INTESTINE	TTK →	+0.618	+3.212	.003	.006	3	1
LARGE_INTESTINE	CCNG1 →	+0.793	+3.212	.001	.006	3	1
LARGE_INTESTINE	MRPS15 →	+0.527	+3.299	.001	.004	3	1
LARGE_INTESTINE	RPAP2 →	+0.840	+3.212	<.001	.006	3	1
LARGE_INTESTINE	ALKBH7 →	+0.428	+3.212	.009	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 74 associations by consensus.

B9D1 by DNPEP expression — LARGE_INTESTINE

Explore this box plot interactively →