DNMT3L

Across TCGA pan-cancer cohorts, DNMT3L Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DNMT3L data layer compared with 26 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher DNMT3L Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNMT3L expression acts as an unfavorable survival marker.

LUSC, COAD, and UCEC are the cancer types where DNMT3L Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.043	0.819	<.001	12	view →
COAD	OS	Median	All	0.181	0.806	.002	12	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DNMT3L–LUSC (OS)

Open the LUSC breakdown →