DNMT3L

Across TCGA patient cohorts, DNMT3L RNA expression is significantly associated with the go_rna of many other GO terms, with 6,913 significant associations in total. STAD shows the largest number of these associations.

The most reproducible DNMT3L-associated GO terms across cancer lineages are Nucleoside triphosphate metabolic process, Protein K11-linked ubiquitination, and Mitochondrial transport. Each is linked with DNMT3L in more than 15 cancer types. Because this analysis shows association rather than direction, both DNMT3L-to-partner and partner-to-DNMT3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nucleoside triphosphate metabolic process grouped by DNMT3L-low versus DNMT3L-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3L→partner) and Y-score (partner→DNMT3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Nucleoside triphosphate metabolic process →	+0.063	+0.157	<.001	<.001	3	16
STAD	Protein K11-linked ubiquitination →	+0.059	+0.156	<.001	<.001	3	16
STAD	Mitochondrial transport →	+0.065	+0.167	<.001	<.001	3	15
STAD	Protein-RNA complex organization →	+0.064	+0.152	<.001	<.001	3	15
STAD	Mitochondrial translation →	+0.074	+0.157	<.001	<.001	3	15
STAD	Mitochondrial gene expression →	+0.073	+0.180	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,913 associations by consensus.

Nucleoside triphosphate metabolic process by DNMT3L expression — STAD

Explore this box plot interactively →