DNMT3L

Across TCGA cell cohorts, DNMT3L RNA expression is significantly associated with the go_rna of many other GO terms, with 1,113 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DNMT3L-associated GO terms across cancer lineages are Lactone catabolic process, Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway, and Negative regulation of CD4-positive, alpha-beta T cell activation. Each is linked with DNMT3L in more than 4 cancer types. Because this analysis shows association rather than direction, both DNMT3L-to-partner and partner-to-DNMT3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lactone catabolic process grouped by DNMT3L-low versus DNMT3L-high in BLOOD_Lymphoma.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3L→partner) and Y-score (partner→DNMT3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	Lactone catabolic process →	-0.667	-0.140	.005	.001	3	5
BLOOD_Lymphoma	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.051	+0.135	<.001	.002	3	4
BLOOD_Lymphoma	Negative regulation of CD4-positive, alpha-beta T cell activation →	-0.076	-0.186	<.001	.002	3	4
BLOOD_Lymphoma	Positive regulation of double-strand break repair →	+0.040	+0.196	.002	.001	3	4
BLOOD_Lymphoma	Negative regulation of leukocyte activation →	-0.052	-0.196	<.001	.001	3	3
LUNG_NSCLC_LUAD	Glycosaminoglycan metabolic process →	-0.052	-0.040	.008	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,113 associations by consensus.

Lactone catabolic process by DNMT3L expression — BLOOD_Lymphoma

Explore this box plot interactively →