DNMT3L

Across TCGA cell cohorts, DNMT3L mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNMT3L-associated genes across cancer lineages are SLC35G4, MAGEB4, and FTHL17. Each is linked with DNMT3L in more than 1 cancer types. Because this analysis shows association rather than direction, both DNMT3L-to-partner and partner-to-DNMT3L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLC35G4 grouped by DNMT3L-low versus DNMT3L-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT3L→partner) and Y-score (partner→DNMT3L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SLC35G4 →	+0.020	+5.781	<.001	.001	3	1
LARGE_INTESTINE	MAGEB4 →	+0.022	+4.415	<.001	.007	3	1
LARGE_INTESTINE	FTHL17 →	+0.060	+4.415	<.001	.007	3	1
LARGE_INTESTINE	CSN2 →	+0.040	+4.684	<.001	.002	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GKN1 →	+0.045	+4.095	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

SLC35G4 by DNMT3L expression — BREAST

Explore this box plot interactively →