DNMT3L-AS1

Across TCGA pan-cancer cohorts, DNMT3L-AS1 RNA is linked to patient survival in 11 of 34 cancer types, making it the most broadly survival-associated DNMT3L-AS1 data layer.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher DNMT3L-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNMT3L-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

UCEC, KIRC, and HNSC are the cancer types where DNMT3L-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.370	0.683	.001	78	view →
KIRC	DFS	Tertile	II,III,IV	0.585	0.740	.001	74	view →
HNSC	DFS	Tertile	II,III,IV	0.686	0.297	.011	54	view →
KIRP	DFS	Tertile	All	0.736	0.892	<.001	36	view →
UVM	OS	Tertile	All	0.220	0.917	<.001	27	view →
ACC	DFS	Tertile	III,IV	0.046	0.670	.001	18	view →
COAD	OS	Tertile	All	0.761	0.879	.045	12	view →
LUAD	DFS	Tertile	IV	0.671	0.893	.019	12	view →
MESO	OS	Tertile	IV	0.371	0.634	.026	9	view →
DLBC	OS	Median	II,III,IV	0.305	1.000	.015	9	view →
THCA	OS	Tertile	IV	0.832	1.000	.035	9	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DNMT3L-AS1–UCEC (DFS)

Open the UCEC breakdown →