DNMT1

Across TCGA pan-cancer cohorts, DNMT1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of DNMT1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where DNMT1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types DNMT1 is over-expressed in tumor.

HNSC, COAD, and CCRCC are the cancer types where DNMT1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNMT1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.617	<.001	11	view →
COAD	Male	All	+0.490	<.001	11	view →
CCRCC	Female	II,III,IV	+0.438	<.001	11	view →
LSCC	Male	II,III,IV	+0.889	<.001	9	view →
LUAD	Female	III,IV	+0.600	<.001	9	view →
PDAC	All	All	+0.213	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

DNMT1–HNSC

Open the HNSC breakdown →