DNMT1

Across TCGA patient cohorts, DNMT1 mutation is significantly associated with the RNA expression of many other genes, with 3,955 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNMT1-associated genes across cancer lineages are MTFMT, NARS1, and GTF2A2. Each is linked with DNMT1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DNMT1-to-partner and partner-to-DNMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTFMT grouped by DNMT1-low versus DNMT1-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT1→partner) and Y-score (partner→DNMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTFMT →	+0.313	+3.348	.004	.004	3	4
COAD	NARS1 →	+0.437	+3.713	<.001	<.001	3	4
COAD	GTF2A2 →	+0.482	+3.731	.002	<.001	3	4
UCEC	TAF9 →	+0.459	+1.750	<.001	<.001	3	3
COAD	MCM5 →	+0.422	+2.371	.006	.002	3	3
UCEC	CDKN3 →	+0.445	+1.593	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,955 associations by consensus.

MTFMT by DNMT1 expression — COAD

Explore this box plot interactively →