DNMT1

Across TCGA patient cohorts, DNMT1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNMT1-associated genes across cancer lineages are eIF4E, 14-3-3_beta, and ACC1. Each is linked with DNMT1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNMT1-to-partner and partner-to-DNMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by DNMT1-low versus DNMT1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT1→partner) and Y-score (partner→DNMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.131	+2.713	.033	.003	3	3
UCEC	14-3-3_beta →	-0.093	-2.475	.001	.001	3	2
UCEC	ACC1 →	+0.252	+1.713	.017	.024	3	2
UCEC	MEK1 →	+0.268	+1.584	.011	.008	3	2
COAD	ATM →	-0.659	-2.691	<.001	.006	2	3
COAD	Caspase-7-cleavedD198 →	+0.909	+3.186	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

eIF4E by DNMT1 expression — UCEC

Explore this box plot interactively →