DNMT1

Across TCGA cell cohorts, DNMT1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,438 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DNMT1-associated GO terms across cancer lineages are Negative regulation of cell cycle process, Constitutive heterochromatin formation, and Negative regulation of cell cycle phase transition. Each is linked with DNMT1 in more than 19 cancer types. Because this analysis shows association rather than direction, both DNMT1-to-partner and partner-to-DNMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cell cycle process grouped by DNMT1-low versus DNMT1-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT1→partner) and Y-score (partner→DNMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.084	+1.478	<.001	<.001	3	20
STOMACH	Constitutive heterochromatin formation →	+0.113	+1.040	.001	.002	3	20
BLOOD_Myeloma	Negative regulation of cell cycle phase transition →	+0.083	+1.202	<.001	.002	3	20
OESOPHAGUS	Positive regulation of mitotic cytokinesis →	+0.181	+1.216	.002	.001	3	20
OESOPHAGUS	Nuclear division →	+0.112	+1.082	.002	.001	3	20
OESOPHAGUS	Chromosome condensation →	+0.251	+1.404	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,438 associations by consensus.

Negative regulation of cell cycle process by DNMT1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →