DNMT1

Across TCGA cell cohorts, DNMT1 mutation is significantly associated with the RNA expression of many other genes, with 1,454 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DNMT1-associated genes across cancer lineages are PRR23C, PPP6R2, and PARD6A. Each is linked with DNMT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNMT1-to-partner and partner-to-DNMT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRR23C grouped by DNMT1-low versus DNMT1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMT1→partner) and Y-score (partner→DNMT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PRR23C →	+0.007	+3.405	<.001	.005	3	2
BLOOD_Leukemia	PPP6R2 →	+0.449	+3.115	.004	.009	3	2
LARGE_INTESTINE	PARD6A →	+0.918	+3.588	<.001	<.001	3	2
BLOOD_Leukemia	RANGRF →	+0.689	+3.459	<.001	.002	3	2
BLOOD_Leukemia	CAPRIN2 →	+1.017	+2.148	.006	.009	3	2
BLOOD_Leukemia	RFC5 →	+0.585	+2.730	.005	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,454 associations by consensus.

PRR23C by DNMT1 expression — OVARY

Explore this box plot interactively →