DNMBP

Across TCGA patient cohorts, DNMBP mutation is significantly associated with the RNA expression of many other genes, with 5,282 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNMBP-associated genes across cancer lineages are SUV39H2, BUB3, and CHAF1B. Each is linked with DNMBP in more than 3 cancer types. Because this analysis shows association rather than direction, both DNMBP-to-partner and partner-to-DNMBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SUV39H2 grouped by DNMBP-low versus DNMBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMBP→partner) and Y-score (partner→DNMBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SUV39H2 →	+0.359	+2.086	.009	<.001	3	3
UCEC	BUB3 →	+0.504	+1.874	<.001	<.001	3	3
UCEC	CHAF1B →	+0.650	+2.087	<.001	<.001	3	3
UCEC	GFM2 →	+0.564	+2.824	<.001	<.001	3	3
UCEC	NUDT2 →	+0.493	+1.678	<.001	<.001	3	3
UCEC	PBK →	+0.904	+2.098	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,282 associations by consensus.

SUV39H2 by DNMBP expression — UCEC

Explore this box plot interactively →