DNMBP

Across TCGA patient cohorts, DNMBP mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNMBP-associated genes across cancer lineages are mTOR_pS2448, ATM, and PCNA. Each is linked with DNMBP in more than 3 cancer types. Because this analysis shows association rather than direction, both DNMBP-to-partner and partner-to-DNMBP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by DNMBP-low versus DNMBP-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNMBP→partner) and Y-score (partner→DNMBP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.098	-1.664	.028	.019	3	4
UCEC	ATM →	-0.705	-2.273	<.001	<.001	3	4
UCEC	PCNA →	+0.243	+4.087	<.001	<.001	3	3
COAD	PKC-b-II_pS660 →	-0.417	-3.321	.004	.009	3	3
COAD	Cyclin-E2 →	+0.567	+2.593	<.001	.006	3	3
UCEC	PKC-delta_pS664 →	-0.073	-2.222	.043	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

mTOR_pS2448 by DNMBP expression — UCEC

Explore this box plot interactively →