DNM3OS

Across TCGA pan-cancer cohorts, DNM3OS RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated DNM3OS data layer.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher DNM3OS RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DNM3OS expression acts as an unfavorable survival marker, although some lineages such as UCS and SKCM show a favorable association.

KIRP, UCS, and UVM are the cancer types where DNM3OS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Median	II,III,IV	0.697	0.925	<.001	110	view →
UCS	DFS	Tertile	II,III,IV	0.619	0.200	.001	64	view →
UVM	DFS	Tertile	All	0.362	0.719	<.001	63	view →
LGG	DFS	Median	All	0.632	0.823	<.001	54	view →
ACC	DFS	Tertile	II,III,IV	0.265	0.656	.007	35	view →
GBM	DFS	Tertile	All	0.147	0.309	<.001	21	view →
SKCM	OS	Quartile	IV	0.823	0.238	.010	16	view →
KIRC	DFS	Tertile	All	0.751	0.523	.008	9	view →
MESO	OS	Quartile	All	0.176	0.424	.031	9	view →
READ	OS	Median	II,III,IV	0.857	0.533	.018	6	view →
PCPG	DFS	Median	All	0.922	0.600	.001	6	view →
BLCA	OS	Tertile	II,III,IV	0.572	0.686	.039	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

DNM3OS–KIRP (OS)

Open the KIRP breakdown →