Across TCGA pan-cancer cohorts, DNM3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DNM3 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DNM3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated DNM3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

CCRCC, LUAD, and PDAC are the cancer types where DNM3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	OS	Quartile	All	0.961	0.694	.002	44	view →
LUAD	DFS	Tertile	All	1.000	0.398	<.001	18	view →
PDAC	DFS	Tertile	All	0.881	0.625	.025	11	view →
GBM	DFS	Tertile	All	0.841	0.623	.012	2	view →
LSCC	OS	Quartile	All	0.971	0.855	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: DNM3 tumor-vs-normal RNA expression · all DNM3 data types