Across TCGA patient cohorts, DNM3 mutation is significantly associated with the RNA expression of many other genes, with 5,777 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM3-associated genes across cancer lineages are CCT5, BUB3, and BUB1B. Each is linked with DNM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNM3-to-partner and partner-to-DNM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM3→partner) and Y-score (partner→DNM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCT5 →	+0.379	+1.993	.003	<.001	3	3
UCEC	BUB3 →	+0.520	+2.187	<.001	<.001	3	3
UCEC	BUB1B →	+0.573	+1.815	<.001	<.001	3	3
UCEC	IDH3A →	+0.376	+1.544	.001	.001	3	3
UCEC	PCLAF →	+0.712	+2.187	<.001	<.001	3	3
UCEC	CHAF1A →	+0.703	+2.895	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,777 associations by consensus.

Exploration

DNM3 survival (RNA) · tumor vs normal (RNA) · all DNM3 data types