DNM3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DNM3 mutation is significantly associated with the total protein of many other genes, with 65 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM3-associated genes across cancer lineages are GAPDH, INPP4B, and MEK1. Each is linked with DNM3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNM3-to-partner and partner-to-DNM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM3→partner) and Y-score (partner→DNM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMGAPDH →+0.476+3.459.021.00532
COADINPP4B →-0.357-2.106.015.01832
UCECMEK1 →+0.353+1.722<.001<.00132
COADMIG-6 →+0.090+3.713.020<.00132
COADmTOR_pS2448 →-0.202-3.309.004.00923
COADRAD51 →+0.151+2.815.014.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 65 associations by consensus.

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