Across TCGA cell cohorts, DNM3 mutation is significantly associated with the mutation status of many other genes, with 6,282 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNM3-associated genes across cancer lineages are GLI2, RIMS2, and FAM227A. Each is linked with DNM3 in more than 4 cancer types. Because this analysis shows association rather than direction, both DNM3-to-partner and partner-to-DNM3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM3→partner) and Y-score (partner→DNM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	GLI2 →	+2.710	+4.203	.008	.008	1	5
UPPER_AERODIGESTIVE_TRACT	RIMS2 →	+2.954	+4.247	.006	.006	1	5
LARGE_INTESTINE	FAM227A →	+3.129	+3.129	<.001	<.001	1	5
PANCREAS	ANKHD1 →	+5.115	+5.115	.005	.005	1	4
PANCREAS	GPR101 →	+5.115	+5.115	.005	.005	1	4
PANCREAS	RBL1 →	+5.115	+5.115	.005	.005	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,282 associations by consensus.

Exploration

DNM3 survival (RNA) · tumor vs normal (RNA) · all DNM3 data types