DNM2

Across TCGA pan-cancer cohorts, DNM2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNM2 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher DNM2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DNM2 expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and GBM are the cancer types where DNM2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.893	.024	30	view →
HNSC	OS	Median	All	1.000	0.449	.023	19	view →
GBM	DFS	Quartile	All	0.641	0.888	.013	4	view →
CCRCC	DFS	Quartile	All	0.630	0.840	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNM2–COAD (DFS)

Open the COAD breakdown →