DNM2

Across TCGA patient cohorts, DNM2 protein abundance is significantly associated with the RNA expression of many other genes, with 13,864 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DNM2-associated genes across cancer lineages are RUVBL1, LIN9, and ZNF639. Each is linked with DNM2 in more than 4 cancer types. Because this analysis shows association rather than direction, both DNM2-to-partner and partner-to-DNM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNM2 versus RUVBL1 in LSCC, with a Pearson correlation of -0.59.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM2→partner) and Y-score (partner→DNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RUVBL1 →	-0.596	-0.126	<.001	<.001	3	5
GBM	LIN9 →	-0.600	-0.202	.001	<.001	3	5
HNSC	ZNF639 →	-0.675	-0.163	.002	.003	3	5
LSCC	CEP63 →	-0.423	-0.112	<.001	<.001	3	5
HNSC	ALMS1 →	-0.604	-0.169	.001	<.001	3	5
LUAD	VRK1 →	-0.539	-0.206	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,864 associations by consensus.

DNM2 vs RUVBL1 — LSCC

Explore this scatter interactively →