DNM2

Across TCGA patient cohorts, DNM2 mutation is significantly associated with the total protein of many other genes, with 62 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM2-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and c-Kit. Each is linked with DNM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNM2-to-partner and partner-to-DNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DNM2-low versus DNM2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM2→partner) and Y-score (partner→DNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.082	+3.169	.003	.018	3	3
UCEC	PCNA →	+0.243	+2.321	.001	.001	3	3
STAD	c-Kit →	-0.450	-3.169	.003	.019	3	2
STAD	Cyclin-E2 →	+0.192	+3.190	.003	.009	3	2
UCEC	eEF2 →	+0.425	+3.584	<.001	.002	3	2
UCEC	ETS-1 →	+0.236	+2.459	.039	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 62 associations by consensus.

Caspase-7-cleavedD198 by DNM2 expression — COAD

Explore this box plot interactively →