DNM2

Across TCGA cell cohorts, DNM2 mutation is significantly associated with the RNA expression of many other genes, with 669 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNM2-associated genes across cancer lineages are OR10T2, NUP43, and MMS22L. Each is linked with DNM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM2-to-partner and partner-to-DNM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by DNM2-low versus DNM2-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM2→partner) and Y-score (partner→DNM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	2
LARGE_INTESTINE	NUP43 →	+0.578	+3.502	.001	.001	3	2
LARGE_INTESTINE	MMS22L →	+0.688	+2.451	.007	.009	3	2
LARGE_INTESTINE	SCAI →	+0.491	+2.451	.009	.009	3	2
BLOOD_Leukemia	CEP57L1 →	+0.709	+3.489	.002	.001	3	2
BLOOD_Leukemia	RIC8B →	+0.682	+3.489	.004	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 669 associations by consensus.

OR10T2 by DNM2 expression — BREAST

Explore this box plot interactively →