DNM1P50

Across TCGA pan-cancer cohorts, DNM1P50 RNA is linked to patient survival in 8 of 34 cancer types, making it the most broadly survival-associated DNM1P50 data layer.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNM1P50 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNM1P50 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

HNSC, KIRC, and ESCA are the cancer types where DNM1P50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	All	0.159	0.713	<.001	72	view →
KIRC	DFS	Tertile	II,III,IV	0.051	0.771	<.001	48	view →
ESCA	DFS	Tertile	III,IV	0.201	0.451	.031	27	view →
LUAD	OS	Tertile	II,III,IV	0.141	0.677	.002	18	view →
PRAD	DFS	Tertile	All	0.099	0.886	<.001	18	view →
THCA	DFS	Tertile	IV	0.406	0.879	.004	12	view →
GBM	DFS	Tertile	All	0.501	0.192	.034	9	view →
KIRP	OS	Tertile	All	0.254	0.716	.031	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

DNM1P50–HNSC (DFS)

Open the HNSC breakdown →