DNM1P47

Across TCGA patient cohorts, DNM1P47 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM1P47-associated genes across cancer lineages are PCNA, STAT3_pY705, and c-Met_pY1235. Each is linked with DNM1P47 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1P47-to-partner and partner-to-DNM1P47 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DNM1P47-low versus DNM1P47-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1P47→partner) and Y-score (partner→DNM1P47) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.414	+3.321	<.001	.010	3	2
UCEC	STAT3_pY705 →	-0.649	-3.159	<.001	.019	3	2
UCEC	c-Met_pY1235 →	+0.096	+2.179	.013	.034	3	2
UCEC	A-Raf_pS299 →	-0.138	-3.000	.028	.036	3	1
UCEC	FOXO3a_pS318_S321 →	-0.166	-3.160	.011	.019	3	1
UCEC	GSK3-a-b →	+0.180	+3.321	.011	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

PCNA by DNM1P47 expression — UCEC

Explore this box plot interactively →