DNM1L

Across TCGA pan-cancer cohorts, DNM1L mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated DNM1L data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DNM1L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated DNM1L expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where DNM1L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.614	0.885	<.001	18	view →
CCRCC	DFS	Tertile	III,IV	0.435	0.714	.019	14	view →
PDAC	OS	Median	III,IV	0.853	0.367	.003	10	view →
LSCC	DFS	Quartile	All	0.961	0.859	.037	3	view →
GBM	DFS	Median	All	0.860	0.646	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

DNM1L–LUAD (OS)

Open the LUAD breakdown →