DNM1L

Across TCGA patient cohorts, DNM1L mutation is significantly associated with the RNA expression of many other genes, with 2,094 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM1L-associated genes across cancer lineages are LYPLA1P1, POLE2, and AAGAB. Each is linked with DNM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1L-to-partner and partner-to-DNM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYPLA1P1 grouped by DNM1L-low versus DNM1L-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1L→partner) and Y-score (partner→DNM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	LYPLA1P1 →	+0.041	+4.912	<.001	.005	3	2
UCEC	POLE2 →	+0.408	+1.721	.004	.001	3	2
UCEC	AAGAB →	+0.390	+1.743	.001	.001	3	2
UCEC	ACBD5 →	+0.442	+2.222	.002	<.001	3	2
UCEC	C1QBP →	+0.373	+1.473	.009	.007	3	2
UCEC	ICE2 →	+0.416	+1.732	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,094 associations by consensus.

LYPLA1P1 by DNM1L expression — HNSC

Explore this box plot interactively →