DNM1L

Across TCGA patient cohorts, DNM1L mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM1L-associated genes across cancer lineages are MEK1, C-Raf, and eIF4E. Each is linked with DNM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1L-to-partner and partner-to-DNM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by DNM1L-low versus DNM1L-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1L→partner) and Y-score (partner→DNM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.361	+2.502	.003	.001	3	2
UCEC	C-Raf →	+0.152	+1.678	.001	.021	3	2
UCEC	eIF4E →	+0.151	+2.087	.032	.005	3	1
UCEC	eIF4G →	+0.234	+2.000	.024	.029	3	1
UCEC	A-Raf_pS299 →	-0.102	-1.415	.010	.043	3	1
UCEC	GAPDH →	+0.438	+2.459	.014	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MEK1 by DNM1L expression — UCEC

Explore this box plot interactively →