DNM1L

Across TCGA cell cohorts, DNM1L mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible DNM1L-associated genes across cancer lineages are ASB17, C12orf40, and PRDM14. Each is linked with DNM1L in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1L-to-partner and partner-to-DNM1L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASB17 grouped by DNM1L-low versus DNM1L-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1L→partner) and Y-score (partner→DNM1L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
BREAST	PRDM14 →	+0.014	+4.232	<.001	.002	3	1
BREAST	ADAD1 →	+0.025	+3.672	<.001	.006	3	1
BREAST	OR10W1 →	+0.008	+4.196	<.001	.006	3	1
BREAST	NANOS2 →	+0.025	+3.906	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ASB17 by DNM1L expression — OVARY

Explore this box plot interactively →