DNM1

Across TCGA pan-cancer cohorts, DNM1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DNM1 data layer compared with 27 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DNM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNM1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where DNM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.231	0.521	.001	27	view →
LUAD	DFS	Median	All	0.971	0.836	.003	11	view →
CCRCC	DFS	Median	IV	0.781	0.220	.017	9	view →
UCEC	OS	Quartile	III,IV	0.339	1.000	.036	8	view →
HNSC	DFS	Median	IV	0.571	0.831	.013	4	view →
LSCC	OS	Tertile	All	0.684	1.000	.040	1	view →
GBM	DFS	Tertile	All	0.841	0.668	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DNM1–PDAC (DFS)

Open the PDAC breakdown →