DNM1

Across TCGA patient cohorts, DNM1 mutation is significantly associated with the RNA expression of many other genes, with 1,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNM1-associated genes across cancer lineages are GEMIN8P3, ADNP2, and LRRC59. Each is linked with DNM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DNM1-to-partner and partner-to-DNM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GEMIN8P3 grouped by DNM1-low versus DNM1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1→partner) and Y-score (partner→DNM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GEMIN8P3 →	+0.113	+4.912	<.001	.005	3	3
UCEC	ADNP2 →	+0.545	+1.805	<.001	.007	3	3
UCEC	LRRC59 →	+0.430	+2.329	.001	<.001	3	3
UCEC	PSMC3IP →	+0.480	+2.828	.001	.001	3	3
UCEC	PRIMPOL →	+0.360	+1.793	.005	.003	3	3
UCEC	SFXN1 →	+0.461	+2.321	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,974 associations by consensus.

GEMIN8P3 by DNM1 expression — HNSC

Explore this box plot interactively →