DNM1

Across TCGA cell cohorts, DNM1 mutation is significantly associated with the RNA expression of many other genes, with 1,235 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNM1-associated genes across cancer lineages are ONECUT1, FOXE3, and GPRIN2. Each is linked with DNM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DNM1-to-partner and partner-to-DNM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ONECUT1 grouped by DNM1-low versus DNM1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNM1→partner) and Y-score (partner→DNM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ONECUT1 →	+0.718	+3.641	<.001	.002	3	2
LARGE_INTESTINE	FOXE3 →	+0.122	+3.526	<.001	<.001	3	2
LARGE_INTESTINE	GPRIN2 →	+1.099	+2.502	<.001	.005	3	2
LUNG_NSCLC_LUAD	OPRPN →	+0.057	+4.887	<.001	.009	3	2
LARGE_INTESTINE	ANKRD54 →	+0.535	+3.237	<.001	.003	3	2
LARGE_INTESTINE	JOSD1 →	+0.585	+2.502	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,235 associations by consensus.

ONECUT1 by DNM1 expression — BLOOD_Leukemia

Explore this box plot interactively →