Across TCGA pan-cancer cohorts, DNER Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DNER data layer compared with 20 for mass-spec protein.
The strongest signal is observed in uveal melanoma (UVM), where higher DNER Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DNER expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.
UVM, UCEC, and SCLC are the cancer types where DNER Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.