Across TCGA patient cohorts, DNER RNA expression is significantly associated with the protein abundance of many other proteins, with 10,965 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DNER-associated proteins across cancer lineages are STRBP, IRS2_S1100, and IRS2_S577. Each is linked with DNER in more than 3 cancer types. Because this analysis shows association rather than direction, both DNER-to-partner and partner-to-DNER results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNER→partner) and Y-score (partner→DNER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STRBP →	-0.504	-0.918	<.001	<.001	3	4
UCEC	IRS2_S1100 →	+1.248	+1.285	<.001	<.001	3	4
UCEC	IRS2_S577 →	+0.912	+1.636	<.001	<.001	3	4
BRCA	NAMPT →	+0.629	+0.728	<.001	.004	3	3
CCRCC	NNMT →	+1.104	+1.157	<.001	.001	3	3
BRCA	MT1X →	+0.612	+0.960	.002	<.001	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,965 associations by consensus.

Exploration

DNER survival (RNA) · tumor vs normal (RNA) · all DNER data types