Across TCGA patient cohorts, DNER protein abundance is significantly associated with the RNA expression of many other genes, with 3,769 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DNER-associated genes across cancer lineages are YPEL1, SNRPD3, and GRK3. Each is linked with DNER in more than 1 cancer types. Because this analysis shows association rather than direction, both DNER-to-partner and partner-to-DNER results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNER→partner) and Y-score (partner→DNER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	YPEL1 →	+0.534	+0.511	.001	.001	3	1
GBM	SNRPD3 →	+0.376	+0.390	<.001	.004	3	1
GBM	GRK3 →	+0.426	+0.492	<.001	<.001	3	1
GBM	SEZ6L →	+1.618	+0.463	<.001	<.001	3	1
GBM	POLR2F →	+0.415	+0.494	<.001	<.001	3	1
GBM	SOX10 →	+1.579	+0.498	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,769 associations by consensus.

Exploration

DNER survival (RNA) · tumor vs normal (RNA) · all DNER data types