Across TCGA patient cohorts, DNER mutation is significantly associated with the total protein of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DNER-associated genes across cancer lineages are 4E-BP1, FASN, and S6. Each is linked with DNER in more than 3 cancer types. Because this analysis shows association rather than direction, both DNER-to-partner and partner-to-DNER results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNER→partner) and Y-score (partner→DNER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.314	+1.632	<.001	<.001	3	4
LUAD	FASN →	+0.589	+3.169	.005	.018	3	3
LUAD	S6 →	+0.321	+3.000	.015	.035	3	2
UCEC	eEF2 →	+0.244	+0.947	.015	.047	3	2
UCEC	EGFR_pY1068 →	-0.205	-1.447	.003	.002	3	2
UCEC	ACVRL1 →	-0.082	-1.333	.033	.013	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Exploration

DNER survival (RNA) · tumor vs normal (RNA) · all DNER data types