Across TCGA cell cohorts, DNER mutation is significantly associated with the RNA expression of many other genes, with 159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DNER-associated genes across cancer lineages are GPR101, PIH1D1, and OR13D1. Each is linked with DNER in more than 2 cancer types. Because this analysis shows association rather than direction, both DNER-to-partner and partner-to-DNER results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DNER→partner) and Y-score (partner→DNER) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GPR101 →	+0.009	+3.472	.001	.004	3	3
LARGE_INTESTINE	PIH1D1 →	+0.476	+3.169	.006	.006	3	2
LARGE_INTESTINE	OR13D1 →	+0.021	+2.397	<.001	.003	3	2
LARGE_INTESTINE	USP17L7 →	+0.053	+3.070	<.001	<.001	3	2
LARGE_INTESTINE	RNF148 →	+0.256	+2.537	.001	.008	3	2
LUNG_NSCLC_LUAD	SNTG2 →	+0.474	+2.879	.007	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 159 associations by consensus.

Exploration

DNER survival (RNA) · tumor vs normal (RNA) · all DNER data types