DNASE2B

Across TCGA pan-cancer cohorts, DNASE2B mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DNASE2B data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher DNASE2B mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DNASE2B expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

HNSC, PDAC, and UCEC are the cancer types where DNASE2B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.571	0.899	.003	23	view →
PDAC	DFS	Median	III,IV	0.992	0.277	<.001	20	view →
UCEC	DFS	Median	All	0.723	1.000	.042	12	view →
LUAD	DFS	Quartile	II,III,IV	0.617	0.875	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DNASE2B–HNSC (DFS)

Open the HNSC breakdown →