DNASE2B

Across TCGA pan-cancer cohorts, DNASE2B mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of DNASE2B’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where DNASE2B mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DNASE2B is over-expressed in tumor, although a few such as LUAD and LSCC show the opposite, repressed pattern.

LUAD, LSCC, and HNSC are the cancer types where DNASE2B tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DNASE2B mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	III,IV	−0.926	<.001	9	view →
LSCC	Male	All	−1.112	<.001	7	view →
HNSC	All	III,IV	−0.331	.002	7	view →
PDAC	All	III,IV	−0.581	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

DNASE2B–LUAD

Open the LUAD breakdown →