DNASE2B

Across TCGA patient cohorts, DNASE2B RNA expression is significantly associated with the protein abundance of many other proteins, with 8,477 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible DNASE2B-associated proteins across cancer lineages are IQGAP2, IQGAP2_S16, and RPL7L1. Each is linked with DNASE2B in more than 4 cancer types. Because this analysis shows association rather than direction, both DNASE2B-to-partner and partner-to-DNASE2B results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DNASE2B versus IQGAP2 in BRCA, with a Pearson correlation of 0.33.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DNASE2B→partner) and Y-score (partner→DNASE2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IQGAP2 →	+0.782	+0.958	<.001	.006	3	5
BRCA	IQGAP2_S16 →	+0.713	+1.138	<.001	<.001	3	5
LSCC	RPL7L1 →	-0.422	-0.444	<.001	<.001	3	4
CCRCC	SH2D1A →	+0.851	+0.945	<.001	<.001	3	4
LSCC	HLA-DRA →	+0.558	+0.471	<.001	<.001	3	4
CCRCC	NPL →	+0.781	+1.002	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,477 associations by consensus.

DNASE2B vs IQGAP2 — BRCA

Explore this scatter interactively →